Her brother-in-law and Pakistan Muslim League-Nawaz (PML-N) President, Shehbaz Sharif, and her son, Hussain Nawaz, confirmed that the former first lady breathed her last at a clinic in London.
The Sharif family has made a decision to bring back her body to Pakistan from London.
She would not take to politics again until previous year, after her husband - now prime minister again - was disqualified by the Supreme Court from holding a public office.
Kulsoom Nawaz, the wife of deposed prime minister Nawaz Sharif, passed away in London on Tuesday after suffering from complications related to cancer.
For her undergraduate studies, Begum Kulsoom Nawaz attended the Forman Christian College and then pursued a Masters degree at the Punjab University.
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Her first direct exposure to the harsh political landscape of Pakistan came in October 1999 when her husband's government was toppled and he was imprisoned.
Kulsoom Sharif was briefly a member of parliament from September 2017 to July 2018 when she won her husband's former seat in a by-election after the Supreme Court disqualified him.
Conspiracy theories claiming that Nawaz was actually healthy, and that the Sharifs were faking her illness to gain sympathy, swirled in the final weeks of the acrimonious campaign.
Kulsoom Nawaz Sharif died after months in a coma. However, she was soon forced to move to London for treatment, and was unable to return and formally take oath for the seat.
Begum Kulsoom led defiant, lonely protests against the Musharraf regime to get her husband freed from prison.
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There was some initial criticism of the PML-N leadership by those who saw the trip overseas as evidence the party was taking its voters for granted.
In a 2012 interview with a local weekly, Maryam had said her mother "dauntlessly challenged the usurper when a lot of men backed out..." He also directed the Pakistan High Commission in London to assist in the provision of all necessary facilities to the heirs of the deceased.
"May Allah bless the departed soul eternal peace at Heaven", he remarked.
Politicians from various political parties and high-level government officials also expressed deep grief over the death.
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