Now ranked only 21st in the world, with his career stalling since his 12th Grand Slam title at the 2016 French Open, last year's Wimbledon saw him retire in the quarter-finals with a season-ending elbow injury.
The Serbian has rediscovered his mojo at SW19 and has looked more alike the former world No 1 who once held all four Grand Slam titles at one time in 2016. "I had a couple of chances, but he played a good full game".
Anger and cutting a disconsolate figure has been a running theme for Djokovic at Wimbledon this year.
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However, Djokovic was unable to maintain his level and it was Nishikori who broke for 3-1 and took the second set.
Djokovic's mood was not improved by Ramos choosing not to punish Nishikori for imitating his earlier offence of bashing a racquet into the ground.
At the start of the second, Djokovic was putting Nishikori under enormous pressure again, but the Japanese held firm on serve in a 10-minute game.
Djokovic now awaits Rafael Nadal or Juan Martin del Potro and on Friday will contest his first All England Club semi-final since 2015.
'I didn't harm the grass. Djokovic is a national hero and I thank him for it, but how can you support Croatia, how don't you feel ashamed? "I'm a different person, different player today".
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State Department spokeswoman Heather Nauert said North Korea called at midday Thursday and offered to meet on Sunday instead. Between 1996 and 2005, some 33 recovery operations were conducted in North Korea which saw 200 sets of remains returned.
Djokovic looked in control in the first set.
Defending champion Roger Federer has been knocked out of Wimbledon after wasting a match point during a 2-6, 6-7 (5), 7-5, 6-4, 13-11 defeat to Kevin Anderson of South Africa on Wednesday. He made a couple of great shots but I managed to break and get back into the set.
"It motivates me to do extremely well here because I don't want to sit here and explain my loss".
"It took me two or three months and that was frustrating that I wasn't able to perform the game that I was used to and the level of tennis I wanted to play".
When Nishikori then bounced his own racket against the court in the fourth set without being given a warning, Djokovic yelled out "double standards" toward the umpire's chair - drawing boos from the Centre Court crowd.
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"Post-match I heard that the organisers were planning to cancel my match if Monfils and Anderson went to a fifth".