In the aftermath of Washington's pullout, Europeans are seeking ways to protect the interests of their firms doing business in Iran and help them escape the brunt of the upcoming U.S. sanctions.
Khamenei said this week he is highly doubtful that Europe will provide the "real guarantees" needed for Iran to stay in the nuclear deal.
Iran has been in discussions with countries involved in the 2015 agreement in an attempt to save the deal after the United States withdrawal.
Trump's decision on Tuesday to renege on the 2015 nuclear accord with Iran and reimpose sanctions against Tehran came with the threat of penalties against any foreign firms involved in business there.
The top Iranian diplomat made the comments at a meeting on Monday with his Russian counterpart, Sergei Lavrov, in Moscow, the second destination on his diplomatic tour aimed at saving the nuclear deal, officially called the Joint Comprehensive Plan of Action (JCPOA).
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Iran has said it is preparing to resume "industrial-scale" uranium enrichment "without any restrictions" unless Europe can provide solid guarantees that it can maintain trade ties despite renewed USA sanctions.
"So far we have had very positive signals from signatories of the deal. but what is important is for Europeans to find a way to protect their investors from USA penalties (when they invest in Iran)", a senior Iranian diplomat said.
This was part of the flaw of the deal to entice Europe and the United States into economic relations with Iran that eventually would have worked against really holding Iran accountable for violations of the deal.
In a tweet on Sunday, Trump wrote: "Remember how badly Iran was behaving with the Iran Deal in place".
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The head of the influential Revolutionary Guards, Mohammad Ali Jafari, said: "I hope recent events will lead us to end our trust in the West and the Europeans".
The deal expected the Iranian government to abide by three key things - to reduce the centrifuges used to process uranium, slash the stockpile of enriched uranium by 98 per cent and cap uranium enrichment by 3.67 per cent, enough to keep nuclear power plants going but inadequate for making a nuclear warhead.
The deal's proponents say it is crucial to forestalling a nuclear Iran and preventing wider war in the Middle East.
"I'm not the national security decision-maker", Bolton said, adding that Trump "makes the decision and the advice that I give him is between us".
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It takes effect in June 2019 . "During the paperwork, he said 'what are we waiting for?' Dr Nitschke told AAP". Goodall himself had no terminal illness and yet was given lethal medication", Valliere said.
Bolton expressed optimism that European allies will follow Trump's lead and exit the deal, despite the assertions of the leaders of France, the United Kingdom, and Germany that they intend to remain in the agreement.