In the sixth inning, as things began to unravel, Red Sox fans began one of their favorite chants: "Yankees suck!" Sale has been his usual excellent self in his first three starts.
This performance was his worst since the Red Sox rocked him for eight runs in a 9-5 loss last August 12, one of only just two losses he suffered in the second half of the regular season.
Through the first 10 games Harper leads the league in home runs and is comfortably ahead of the field in drawing walks; incredibly he has hit a home run more often than he has been struck out, highlighting himself as the biggest threat to pitchers in the majors.
The ESPN broadcast showed Severino extending his hands in the second inning before throwing his pitches, which could have been one reason the Red Sox scored four in the first two frames.
A 14-1 rout at Fenway Park with Mookie Betts delivering the knockout punch. Tommy Kahnle walked three batters and surrendered five runs, and Chasen Shreve served up a grand slam to Betts.
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CARDINALS 5, BREWERS 3 (11) Matt Carpenter's two-run home run with no outs in the 11th inning gave host St. Louis a victory over Milwaukee.
The last Boston pitcher to do that in consecutive starts at any point in the season was Clay Buchholz, who did it in April of 2013.
Giancarlo Stanton (2-for-4) struck out twice in his rivalry debut, bringing his season whiff total to a league-high 22. The Yankees themselves sit at 5-6 as they are off to a slower start than many may have anticipated. "That's the guy we know has won a Cy Young award". Price is 15-11 with a 4.53 lifetime ERA against the Yankees.
Both the Mets and the Red Sox boast 9-1 records and have achieved those marks with their pitching.
Giants 5, Diamondbacks 4: Andrew McCutchen's second walk-off hit in four days, a bases-loaded single in the bottom of the ninth inning, delivered San Francisco a victory over visiting Arizona.
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Homer Bailey was terrific for the Reds, allowing one earned run and two hits while striking out seven in six innings.
When Stanton whiffed in the opening inning there was one out, a runner on first and no score.
Giancarlo Stanton was expected to make a huge impact for the New York Yankees after he was traded from the Miami Marlins.
Severino allowed only a single in the fifth inning before being lifted after 94 pitches.
The 1-2-3 hitters for Boston - Betts, Andrew Benintendi and Ramirez ended the game on Tuesday 8-for-9, four base on balls, eight runs and nine runs batted in.
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The Yankees had the infielders in on the diamond grass for Hanley Ramirez. The reigning AL Rookie of the Year went 0-for-12 with 10 strikeouts off Sale last season before going 3-for-3 with a 444-foot home run to dead center Tuesday night.