Next up for Garoppolo are the Houston Texans, who have lost their past two games.
After taking the hit, Savage spent time talking to the team's medical staff.
The 49ers second touchdown drive came in the third quarter and spanned just 6 plays and 3:33.
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"They try to make the best decision for the player", O'Brien said.
Houston quarterback Tom Savage was cleared to re-enter Sunday's game against the San Francisco 49ers for one series after sustaining a concussion, raising questions about the NFL's procedure for evaluating such injuries during games.
Savage and Yates are the only quarterbacks on Houston's roster, so they'll have to sign someone this week to back up Yates if Savage is unable to play on Sunday. His 41-yard field goal with 3:50 left in the fourth quarter put the 49ers up two scores. "We've got to do a better job of distributing the ball around because if they do that to him there should be other guys open". The Texans erased that 13-9 halftime deficit on their first drive of the third quarter, but the 49ers kept rolling behind Garoppolo and surged ahead for good in the waning moments of that period.
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T.J. Yates replaced Savage in the game and led touchdown drives on his first two possessions. However, Houston's prospects of victory likely lie with how their struggling offensive line protects a turnover-prone quarterback in Tom Savage. If Savage did indeed suffer a concussion, there will have to be a major response by the National Football League as to why he was allowed back on the field with several fail-safes used to try and prevent such an action.
Yates is an experienced backup who has completed 58.1 percent of his career throws for 1,534 yards, six touchdowns and eight interceptions.
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